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Allosteric modulation company Addex Pharmaceuticals Ltd (SIX: ADXN) announced today that it has observed efficacy in a model of Alzheimer's disease using a recently discovered orally-available drug-candidate. The proprietary molecule specifically inhibits a receptor subtype called the metabotropic glutamate receptor 2 (mGluR2) via negative allosteric modulation (NAM). An Addex mGluR2 NAM is scheduled to enter Phase I clinical testing in healthy volunteers during 2011. (Source: Pharmaceutical Online News)
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Seasalt knitting shops launch the GO KNIT! charity knitting project to support Alzheimer's Society. (Source: Alzheimers Society)
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David Wilson Homes South West have set themselves the challenge of raising £5,000 for Alzheimer's Society. (Source: Alzheimers Society)
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Eisai Co., Ltd. (Headquarters: Tokyo, Japan, President & CEO: Haruo Naito, "Eisai") announced today the start of the first patient enrolled clinical study with BAN2401, a novel monoclonal antibody that is being developed as a potential next-generation therapeutic treatment for Alzheimer's disease...
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Treatments modelled on the cancer drug Gleevec could potentially prevent the formation of amyloid plaques - one of the major hallmarks of Alzheimerâs disease according to a new study. (Source: Alzheimers Society)
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NEW YORK (Reuters Health) - While staying mentally active in old age has been linked to a delayed onset of dementia, seniors who engage in such brain "exercise" may actually have a faster rate of decline once Alzheimer's is diagnosed, researchers reported Wednesday. (Source: Reuters: Health)
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Eisai Co., Ltd. (Headquarters: Tokyo, Japan, President & CEO: Haruo Naito, "Eisai") announced today the start of the first patient enrolled clinical study with BAN2401, a novel monoclonal antibody that is being developed as a potential next-generation therapeutic treatment for Alzheimer's disease. BAN2401 is the first monoclonal antibody to selectively bind, neutralize and eliminate soluble protofibrils, the toxic amyloid-beta aggregates thought to cause Alzheimer's disease... (Source: Health News from Medical News Today)
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If you buy or sell on eBay you can vote for us as your favourite charity and help us win a £5,000 grant. (Source: Alzheimers Society)
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Shock Absorber, the UKâs leading sports bra brand, is boosting Alzheimerâs Society fundraising efforts by offering runners in the Bupa Great North, South and Yorkshire Runs a 10% discount. (Source: Alzheimers Society)
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In Alzheimer’s disease, the problem is beta-amyloid, a protein that accumulates in the brain and causes nerve cells to weaken and die. Drugs designed to eliminate plaques made of beta-amyloid have a fatal problem: they need to enter the brain and remove the plaques without attacking healthy brain cells…
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