Author Archive
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Jul 22, 2010
No CommentsOptimizing the CAMCOG test in the screening for mild cognitive impairment and incipient dementia: saving time with relevant domains
To identify the CAMCOG sub-items that best contribute for the identification of patients with mild cognitive impairment (MCI) and incipient Alzheimer's disease (AD) in clinical practice.Cross-sectional assessment of 272 older adults (98 MCI, 82 AD, and 92 controls) with a standardized neuropsychological battery and the CAMCOG schedule. Backward logistic regression analysis with diagnosis (MCI and...
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Jul 14, 2010
No CommentsEpidemiological studies of cognitive impairment and dementia across Eastern and Middle European countries (epidemiology of dementia in Eastern and Middle European Countries)
To determine the availability and the consistency of prevalence findings of epidemiological studies on cognitive impairment and dementia conducted in Eastern and Middle Europe.We adopted a stepwise multimethod study approach consisting of iterative literature searches for epidemiological articles published between 1990 and 2006 and subsequent data analyses of published material, reanalyses of existing accessible epidemiological...
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Jul 06, 2010
No CommentsRelationship between cognition and awareness of deficit in mild cognitive impairment
Although anosognosia is common in Alzheimer's disease (AD), limited research has investigated awareness among patients with mild cognitive impairment (MCI). The current study examined cognitive performance differences between MCI patients who were aware or unaware of their deficits.Participants were 65 patients who underwent a comprehensive neuropsychological evaluation and diagnosed with MCI according to Petersen's criteria....
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Jul 02, 2010
No CommentsEffect of donepezil on emergence of apathy in mild to moderate Alzheimer’s disease
To determine whether donepezil treatment (10 mg/day over 24 weeks) is associated with delayed emergence of apathy in patients with mild to moderate Alzheimer's disease (AD) and to explore relationships between donepezil's effects on apathy and other Neuropsychiatric Inventory (NPI)-measured behavioural symptoms.Two randomised, double-blind, parallel-group, placebo-controlled studies that met prespecified criteria and were sufficiently similar...
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May 25, 2010
No CommentsEfficacy of rivastigmine transdermal patch on activities of daily living: item responder analyses
In Alzheimer's disease (AD), rivastigmine has demonstrated statistically significant efficacy versus placebo on cognition and activities of daily living (ADL). The aim of this retrospective analysis was to further evaluate the treatment effects of rivastigmine on individual ADL items.This exploratory analysis focused on the Alzheimer's Disease Cooperative Study Activities of Daily Living (ADCS-ADL) outcome from...
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Apr 26, 2010
No CommentsRelation between frontal lobe symptoms and dementia severity within and across diagnostic dementia categories
To study frontal lobe symptoms in relation to dementia severity within and across diagnostic dementia categories, a cross-sectional analysis of behavioural data was performed.Patients with probable Alzheimer's disease (AD) (n = 456), frontotemporal dementia (FTD) (n = 55) and dementia with Lewy bodies (DLB) (n = 48) were included. Dementia severity and frontal lobe symptoms...
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Apr 26, 2010
No CommentsRelation between frontal lobe symptoms and dementia severity within and across diagnostic dementia categories
To study frontal lobe symptoms in relation to dementia severity within and across diagnostic dementia categories, a cross-sectional analysis of behavioural data was performed.Patients with probable Alzheimer's disease (AD) (n = 456), frontotemporal dementia (FTD) (n = 55) and dementia with Lewy bodies (DLB) (n = 48) were included. Dementia severity and frontal lobe symptoms...
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Apr 20, 2010
No CommentsDetecting prodromal Alzheimer’s disease in mild cognitive impairment: utility of the CAMCOG and other neuropsychological predictors
The objectives of this study are: to establish which subtests of cognitive domains contained within the CAMCOG are predictive of conversion to AD, to compare these with an extended version of the delayed word recall (DWR) test and to establish optimal cut points for all measures used.182 patients with MCI were identified from consecutive referrals...
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Apr 19, 2010
No CommentsAnxiety and behavioural disturbance as markers of prodromal Alzheimer’s disease in patients with mild cognitive impairment
The objectives of this study are to determine which symptoms among a range of neuropsychiatric symptoms known to commonly occur in patients with MCI are predictive of later conversion to AD. We also wish to determine whether these symptoms track existing measures of declining cognitive and functional status or may be considered distinct and sensitive...
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Apr 13, 2010
No CommentsThe AddNeuroMed framework for multi-centre MRI assessment of Alzheimer’s disease : experience from the first 24 months
To describe the AddNeuroMed imaging framework for multi-centre magnetic resonance imaging (MRI) assessment of longitudinal changes in Alzheimer's disease and report on early results from the first 24 months of the project.A multi-centre study similarly to a faux clinical trial has been established to assess longitudinal MRI changes in Alzheimer disease (AD), mild cognitive impairment...
