Archive for March 12th, 2010
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Mar 12, 2010
No CommentsDimebon Disappoints: Is There Hope for Novel Alzheimer’s Agent?
The great hope for serendipitous transformation of a shelved antihistamine into an Alzheimer's treatment has been dashed by negative results in phase 3 trials. Medscape Neurology polls experts on what went wrong. Medscape Medical News (Source: Medscape Medical News...
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Mar 12, 2010
1 Comment[News of the Week] Pharmacology: The Puzzling Rise and Fall of a Dark-Horse Alzheimer’s Drug
The announcement last week that a closely watched phase III clinical trial for Alzheimer's disease had failed to show a significant effect deals yet another demoralizing blow to patients, families, and caregivers.Author: Greg Miller (Source: Science: Current...
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Mar 12, 2010
No CommentsMIND Reviews: The Other Brain
The Other Brain: From Dementia to Schizophrenia, How New Discoveries about the Brain Are Revolutionizing Medicine and Science by R. Douglas Fields. [More]
Mar 12, 2010
No CommentsAMP-activated Protein Kinase Signaling Activation by Resveratrol Modulates Amyloid-{beta} Peptide Metabolism [Neurobiology]
Alzheimer disease is an age-related neurodegenerative disorder characterized by amyloid-β (Aβ) peptide deposition into cerebral amyloid plaques. The natural polyphenol resveratrol promotes anti-aging pathways via the activation of several metabolic sensors, including the AMP-activated protein kinase (AMPK). Resveratrol also lowers Aβ levels in cell lines; however, the underlying mechanism responsible for this effect is largely...
Mar 12, 2010
No CommentsLoss of Function of ATXN1 Increases Amyloid {beta}-Protein Levels by Potentiating {beta}-Secretase Processing of {beta}-Amyloid Precursor Protein [Molecular Bases Of Disease]
In this study, we ask whether ATXN1 may lead to AD pathogenesis by affecting Aβ and APP processing utilizing RNA interference in a human neuronal cell model and mouse primary cortical neurons. We show that knock-down of ATXN1 significantly increases the levels of both Aβ40 and Aβ42. This effect could be rescued with concurrent overexpression...
Mar 12, 2010
No CommentsThe Large Hydrophilic Loop of Presenilin 1 Is Important for Regulating {gamma}-Secretase Complex Assembly and Dictating the Amyloid {beta} Peptide (A{beta}) Profile without Affecting Notch Processing [Enzymology]
In this study we have examined the role of the large hydrophilic loop (amino acids 320–374, encoded by exon 10) of presenilin 1 (PS1), the catalytic subunit of -secretase, for -secretase complex formation and activity on Notch and APP processing. Deletion of exon 10 resulted in impaired PS1 endoproteolysis, -secretase complex formation, and had a...
Mar 12, 2010
No CommentsAlzheimerâs Society comment on new research which indicates that individual episodic memory traces can be decoded in hippocampus
Dr Susanne Sorensen comment, (Source: Alzheimers...
Mar 12, 2010
No CommentsNew Alzheimer’s test offers better opportunities
Early detection is key to more effective therapy for Alzheimer's disease and other forms of cognitive impairment, and new research shows that a test developed at the University of Tennessee is more than 95 percent effective in detecting cognitive abnormalities linked to these diseases. The test, called CST -- for computerized self test -- was...
Mar 12, 2010
No CommentsNew Alzheimer’s test offers better opportunities
Early detection is key to more effective therapy for Alzheimer's disease and other forms of cognitive impairment, and new research shows that a test developed at the University of Tennessee is more than 95 percent effective in detecting cognitive abnormalities linked to these diseases. The test, called CST -- for computerized self test -- was...
Mar 12, 2010
No CommentsMimetics of hormetic agents: stress-resistance triggers.
Authors: Sonneborn JS Mimetics of hormetic agents offer a novel approach to adjust dose to minimize the risk of toxic response, and maximize the benefit of induction of at least partial physiological conditioning. Nature selected and preserved those organisms and triggers that promote tolerance to stress. The induced tolerance can serve to...
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