Archive for February 8th, 2010

• Feb 08, 2010

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  How preserved is episodic memory in behavioral variant frontotemporal dementia?

  Conclusions: Our results provide evidence for an underlying memory deficit in "real" or progressive behavioral variant frontotemporal dementia (bvFTD) similar to Alzheimer disease, though the groups differ in orientation scores, with patients with bvFTD being intact. Exclusion solely based on impaired neuropsychological memory performance can potentially lead to an underdiagnosis of FTD. (Source:...
  
  

• Feb 08, 2010

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  Correlation of Longitudinal Cerebrospinal Fluid Biomarkers With Cognitive Decline in Healthy Older Adults [Original Contribution]

  Conclusions  In this group of healthy older adults, changes in CSF biomarker levels previously associated with Alzheimer disease correlated with a decline in cognitive functions. Changes in CSF biomarker levels may identify early neurodegenerative processes of Alzheimer disease. (Source: Archives of...
  
  

• Feb 08, 2010

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  A Randomized, Placebo-Controlled Trial of Latrepirdine in Huntington Disease [Clinical Trials]

  Conclusions  Short-term administration of latrepirdine is well tolerated in patients with HD and may have a beneficial effect on cognition. Further investigation of latrepirdine is warranted in this population with HD. Trial Registration  clinicaltrials.gov Identifier: NCT00497159 (Source: Archives of...
  
  

• Feb 08, 2010

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  The Spectrum of Mutations in Progranulin: A Collaborative Study Screening 545 Cases of Neurodegeneration [Original Contribution]

  Conclusions  Pathogenic mutations were found only in FTD-spectrum cases and not in other related neurodegenerative diseases. Haploinsufficiency of GRN is the predominant mechanism leading to FTD. (Source: Archives of Neurology)

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• Feb 08, 2010

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  Alzheimer Disease-like Phenotype Associated With the c.154delA Mutation in Progranulin [Original Contribution]

  Conclusions  In this large kindred, most affected individuals had clinical presentations that resembled Alzheimer disease or amnestic mild cognitive impairment associated with a mutation in PGRN and underlying FTLD-U with NII neuropathologic abnormalities. This finding is in distinct contrast to previously reported kindreds, in which clinical presentations have typically been within the spectrum of FTLD....
  
  

• Feb 08, 2010

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  Green-Field Virtual Library Launched

  The Alzheimer’s Association Green-Field Library is pleased to announce a new Virtual Library at http://www.alz.org/library. The new web page has been made possible by an Outreach Express Award from NN/LM Greater Midwest Region. Green-Field Library serves diverse populations and an expansive geographic area through the national headquarters in Chicago, Illinois, and a network of...
  
  

• Feb 08, 2010

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  Marijuana ineffective as an Alzheimer’s treatment

  The benefits of marijuana in tempering or reversing the effects of Alzheimer's disease have been challenged in a newly released study by scientists at the University of British Columbia and Vancouver Coastal Health Research Institute. The findings, reported in the current issue of the journal Current Alzheimer Research, could lower expectations about the benefits of...
  
  

• Feb 08, 2010

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  EXPOSED: “Scandalous Abuse” of the Elderly Being Killed With Psychiatric Medications

  (NaturalNews) Elderly dementia patients are being subjected to "scandalous abuse" by being drugged with dangerous antipsychotic drugs, according to a letter by ten influential health organizations, published in The Daily Telegraph."[One hundred thousand] people with dementia in care homes are being inappropriately prescribed a damaging chemical cosh of antipsychotic drugs and new research suggests that...