Archive for February 8th, 2010

• Feb 08, 2010

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  The biggest loser: Maternal obesity puts a load on her offspring that lasts a lifetime

  (Federation of American Societies for Experimental Biology) As if there are not enough reasons for obese people to lose weight, a research report recently published online in The FASEB Journal, adds several more. In a study involving rats, Duke University researchers found that obesity in mothers causes cellular programming in utero that predisposes offspring to...
  
  

• Feb 08, 2010

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  Neuroimaging study may pave way for effective Alzheimer’s treatments

  (University of California - San Francisco) Scientists have determined that a new instrument known as PIB-PET is effective in detecting deposits of amyloid-beta protein plaques in the brains of living people, and that these deposits are predictive of who will develop Alzheimer's disease. (Source: EurekAlert! - Medicine and...
  
  

• Feb 08, 2010

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  Memory lapses are common and increase with age; when do they signal Alzheimer’s?

  Where did I park my car? What is that lady's name? Where are my glasses? Some call these "senior moments" or "tip-of-the-tongue" experiences. They're mundane for many elderly (and not-so-elderly) adults, but when do they become something more serious? How does one know when it's time to get scree... (Source: Wash Post...
  
  

• Feb 08, 2010

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  Randomised trial of latrepirdine in Huntington Disease

  In this study, a total of 91 patients with mild to moderate HD were randomised to double-blind treatment with latrepirdine (20mg TDS; n=46) or placebo (n=45) for 90 days.  The primary outcome was tolerability (ability to complete ... (Source: NeLM - News)

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• Feb 08, 2010

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  Amyloid oligomers: formation and toxicity of Aβ oligomers

  Alzheimer's disease (AD) is an age-related, progressive degenerative disorder that is characterized by synapse and neuron loss in the brain and the accumulation of protein-containing deposits (referred to as 'senile plaques') and neurofibrillary tangles. Insoluble amyloid [beta]-peptide (A[beta]) fibrillar aggregates found in extracellular plaques have long been thought to cause the neurodegenerative cascades of AD....
  
  

• Feb 08, 2010

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  Neuroimaging Study May Pave Way for Effective Alzheimer’s Treatments

  Scientists have determined that a new instrument known as PIB-PET is effective in detecting deposits of amyloid-beta protein plaques in the brains of living people, and that these deposits are predictive of who will develop Alzheimer's disease. (Source: UCSF Medical...
  
  

• Feb 08, 2010

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  Alzheimer’s drug Dimebon helps Huntington’s: study

  WASHINGTON (Reuters) - Dimebon, a pill being developed for Alzheimer's disease, helped people with Huntington's disease improve their thinking, learning and memory skills, U.S. researchers said on Monday. (Source: Reuters:...
  
  

• Feb 08, 2010

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  Alzheimer’s Drug Dimebon Helps Huntington’s

  Dimebon, a pill being developed for Alzheimer's disease, helped people with Huntington's disease improve their thinking, learning and memory skills, U.S. researchers said on Monday. Source: Reuters Health Related MedlinePlus Topics: Alzheimer's Disease, Huntington's Disease (Source: MedlinePlus Health...
  
  

• Feb 08, 2010

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  Gene expression levels as endophenotypes in genome-wide association studies of Alzheimer disease

  Conclusions: These results provide strong evidence that IDE is a late-onset Alzheimer disease (LOAD) gene with variants that modify risk of LOAD by influencing IDE expression. They also suggest that the use of expression levels as endophenotypes in genome-wide association studies may provide a powerful approach for the identification of disease susceptibility alleles. (Source: Neurology)

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• Feb 08, 2010

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  11C-PIB binding is increased in patients with cerebral amyloid angiopathy-related hemorrhage

  Conclusion: 11C-Pittsburgh compound B (PIB) binding is moderately increased in most patients with probable cerebral amyloid angiopathy (CAA)-related intracerebral hemorrhage. The distribution may differ from that seen in Alzheimer disease. 11C-PIB PET may assist in the in vivo diagnosis of CAA and serve as a surrogate marker for future therapeutic studies. (Source:...