Archive for February 7th, 2010
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Feb 07, 2010
No CommentsMarijuana ineffective as an Alzheimer’s treatment: UBC-Vancouver Coastal Health research
(University of British Columbia) The benefits of marijuana in tempering or reversing the effects of Alzheimer's disease have been challenged in a new study by researchers at the University of British Columbia and Vancouver Coastal Health Research Institute. (Source: EurekAlert! - Medicine and...
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Feb 07, 2010
No CommentsMarijuana ineffective as an Alzheimer’s treatment
The benefits of marijuana in tempering or reversing the effects of Alzheimer's disease have been challenged in a new study. (Source: ScienceDaily...
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Feb 07, 2010
No CommentsMedication appears well-tolerated, beneficial in Huntington’s disease patients
(JAMA and Archives Journals) A medication previously studied in patients with Alzheimer's disease (latrepirdine) appears well tolerated and may improve thinking, learning and memory skills among individuals with Huntington's disease, according to a report in the February issue of Archives of Neurology, one of the JAMA/Archives journals. (Source: EurekAlert! - Medicine and...
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Feb 07, 2010
No Comments3D comparison of low, intermediate, and advanced hippocampal atrophy in MCI
We applied the hippocampal radial atrophy mapping technique to the baseline and follow-up magnetic resonance image data of 169 amnestic mild cognitive impairment (MCI) participants in the imaging arm of the Alzheimer's Disease Cooperative Study MCI Donepezil/Vitamin E trial. Sixty percent of the subjects with none to mild hippocampal atrophy rated with the visual medial...
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Feb 07, 2010
No CommentsTransgenic mouse and cell culture models demonstrate a lack of mechanistic connection between endoplasmic reticulum stress and tau dysfunction
In vivo aggregation of tau protein is a hallmark of many neurodegenerative disorders, including Alzheimer's disease (AD). Recent evidence has also demonstrated activation of the unfolded protein response (UPR), a cellular response to endoplasmic reticulum (ER) stress, in AD, although the role of the UPR in disease pathogenesis is not known. Here, three model systems...
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Feb 07, 2010
No CommentsIdentification of novel 1,4-benzoxazine compounds that are protective in tissue culture and in vivo models of neurodegeneration
We report that several 2-arylidine and 2-hetarylidin derivatives of the 1,4-benzoxazines class of compounds are highly protective in tissue culture models of neurodegeneration. Results obtained using pharmcalogical inhibitors indicate that neuroprotection by these compounds does not involve the Raf-MEK-ERK or PI-3 kinase-Akt signaling pathways nor other survival-promoting molecules such as protein kinase A (PKA), calcium...
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Feb 07, 2010
No CommentsFlavonoid transport across RBE4 cells: A blood-brain barrier model.
In conclusion, the tested flavonoids were capable of crossing this blood-brain barrier model. PMID: 20140760 [PubMed - as supplied by publisher] (Source: Cellular and Molecular Biology...
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Feb 07, 2010
No CommentsStrategies to increase the reproducibility of protein fibrillizationin plate reader assays.
Authors: Giehm L, Otzen DE There is great interest in developing reproducible high-throughput screens to identify small molecular inhibitors of protein fibrillization and aggregation for possible therapy against deposition diseases such as Alzheimer's and Parkinson's (PD). We have made a methodical analysis of factors increasing the reproducibility of the fibrillization of alpha-synuclein...
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Feb 07, 2010
No CommentsVerbal memory impairment in subcortical ischemic vascular disease A descriptive analysis in CADASIL.
Authors: Epelbaum S, Benisty S, Reyes S, O'Sullivan M, Jouvent E, Düring M, Hervé D, Opherk C, Hernandez K, Kurtz A, Viswanathan A, Bousser MG, Dichgans M, Chabriat H In the elderly, the high prevalence of Alzheimer's disease neuropathology presents a major challenge to the investigation of memory decline in common diseases...
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Feb 07, 2010
No CommentsTriflusal reduces dense-core plaque load, associated axonal alterations and inflammatory changes, and rescues cognition in a transgenic mouse model of Alzheimer’s disease.
Authors: Coma M, Serenó L, Da Rocha-Souto B, Scotton TC, Espana J, Sánchez MB, Rodríguez M, Agulló J, Guardia-Laguarta C, Garcia-Alloza M, Borrelli LA, Clarimón J, Lleó A, Bacskai BJ, Saura CA, Hyman BT, Gómez-Isla T Inflammation has been associated with the two classic lesions in the Alzheimer's (AD) brain, amyloid deposits...
