Archive for February 5th, 2010

• Feb 05, 2010

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  Concomitant astroglial atrophy and astrogliosis in a triple transgenic animal model of Alzheimer’s disease

  Astrocytes are fundamental for brain homeostasis and are at the fulcrum of neurological diseases including Alzheimer's disease (AD). Here, we monitored changes in astroglia morphology throughout the age-dependent progression of AD. We used an immunohistochemical approach that allows us to determine the domain of glial cytoskeleton, by measuring the surface, volume, and the relationship between...
  
  

• Feb 05, 2010

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  An enzyme-linked immunosorbent assay to compare the affinity of chemical compounds for beta-amyloid peptide as a monomer.

  Authors: Jiang C, Feng Y, Huang X, Xu Y, Zhang Y, Zhou N, Shen X, Chen K, Jiang H, Liu D Abeta(1-42) is the proteolytic cleavage product of cleavage of the amyloid precursor protein by beta- and gamma-secretases. The aggregation of Abeta(1-42) plays a causative role in the development of Alzheimer's disease....
  
  

• Feb 05, 2010

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  Ageing, neurodegeneration and Parkinson’s disease

  Age is the largest risk factor for the development and progression of Parkinson’s disease (PD). Ageing affects many cellular processes that predispose to neurodegeneration, and age-related changes in cellular function predispose to the pathogenesis of PD. The accumulation of age-related somatic damage combined with a failure of compensatory mechanisms may lead to an acceleration of...
  
  

• Feb 05, 2010

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  UK Sanders-Brown to Host Seminar on Healthy Aging

  The University of Kentucky Sanders-Brown Center on Aging and the African-American Dementia Outreach Partnership will host a seminar on "Healthy Aging: Mind, Body and Spirit." The seminar begins at 10:30 a.m. Thursday, Feb. 25, at the North Lexington Family YMCA, 381 W. Loudon Ave. in Lexington. “Increasing awareness of this devastating disease of the brain...
  
  

• Feb 05, 2010

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  Recommended: Gems and Gemstones

  Gems and Gemstones by Lance Grande and Allison Augustyn. University of Chicago Press, 2009 [More]
  
  
  

• Feb 05, 2010

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  Cerebrospinal Fluid Steroidomics: Are Bioactive Bile Acids Present in Brain? [Lipids]

  In this study we have profiled the free sterol content of cerebrospinal fluid by a combination of charge tagging and liquid chromatography-tandem mass spectrometry. Surprisingly, the most abundant cholesterol metabolites were found to be C27 and C24 intermediates of the bile acid biosynthetic pathways with structures corresponding to 7-hydroxy-3-oxocholest-4-en-26-oic acid (7.170 ± 2.826 ng/ml, mean...
  
  

• Feb 05, 2010

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  Progression to Alzheimer’s Linked to Amount of Amyloid in Brain [Clinical & Research News]

  (Source: Psychiatr...