Archive for January 20th, 2010

• Jan 20, 2010

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  People Over 50 Should Cut Copper and Iron Intake

  Copper from home plumbing is one metal that may increase the risk of Alzheimer's disease and other age-related disorders. (Source: Disabled...
  
  

• Jan 20, 2010

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  Does Religiosity Protect Against Cognitive and Behavioral Decline in Alzheimer’s Dementia?

  Authors: Coin A, Perissinotto E, Najjar M, Girardi A, Inelmen EM, Enzi G, Manzato E, Sergi G BACKGROUND: several studies have shown that religiosity has beneficial effects on health, mortality and pathological conditions; little is known about religiosity in Alzheimer's disease and the progression of its cognitive, behavioral and functional symptoms. Our...
  
  

• Jan 20, 2010

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  Induced Pluripotent Stem Cells as a Model for Accelerated Patient- and Disease-specific Drug Discovery.

  Authors: Gunaseeli I, Doss MX, Antzelevitch C, Hescheler J, Sachinidis A Human induced pluripotent stem (iPS) cells hold great promise for therapy of a number of degenerative diseases such as ischemic heart failure, Parkinson's disease, Alzheimer's disease, diabetes mellitus, sickle cell anemia and Huntington disease. They also have the potential to accelerate...
  
  

• Jan 20, 2010

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  ADF/Cofilin-Actin Rods in Neurodegenerative Diseases.

  Authors: Bamburg JR, Bernstein BW, Davis RC, Flynn KC, Goldsbury C, Jensen JR, Maloney MT, Marsden IT, Minamide LS, Pak CW, Shaw AE, Whiteman I, Wiggan O PMID: 20088812 [PubMed - as supplied by publisher] (Source: Current Alzheimer Research)

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• Jan 20, 2010

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  Bridging Neurocognitive Aging and Disease Modification: Targeting Functional Mechanisms of Memory Impairment.

  Authors: Gallagher M, Bakker A, Yassa MA, Stark CE Risk for Alzheimer's disease escalates dramatically with increasing age in the later decades of life. It is widely recognized that a preclinical condition in which memory loss is greater than would be expected for a person's age, referred to as amnestic mild cognitive...
  
  

• Jan 20, 2010

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  Cognitive and Cardiovascular Benefits of Docosahexaenoic Acid in Aging and Cognitive Decline.

  Authors: Yurko-Mauro K Memory loss is a prominent health concern, second only to heart disease for older individuals. Docosahexaenoic acid (DHA), the principle omega-3 fatty acid in brain and heart, plays an important role in neural and cardiac function. Decreases in plasma DHA are associated with cognitive decline in healthy elderly and...
  
  

• Jan 20, 2010

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  Fragile X Syndrome and Alzheimer’s Disease: Another Story about APP and beta-Amyloid.

  Authors: Malter JS, Ray BC, Westmark PR, Westmark CJ As the mechanisms underlying neuronal development and degeneration become clarified, a number of common effectors and signaling pathways are becoming apparent. Here we describe the identification of Abeta, long considered a pathologic mediator of Alzheimers Disease and Down Syndrome, as similarly over-expressed in...
  
  

• Jan 20, 2010

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  Targeted Hydrolysis of Beta-Amyloid with Engineered Antibody Fragment.

  Authors: Kasturirangan S, Sierks M Accumulation and deposition of beta amyloid (Abeta) play a critical role in the pathogenesis of Alzheimer's Disease (AD), and numerous approaches to control Abeta aggregation are being actively pursued. Brain Abeta levels are controlled by the action of several proteolytic enzymes such as neprilysin (NEP), insulin degrading...
  
  

• Jan 20, 2010

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  Disaggregation of Tau as a Therapeutic Approach to Tauopathies.

  Authors: Duff K, Kuret J, Congdon EE Tau aggregation is an appealing target for therapeutic intervention. However, conformational change or aggregation needs to be targeted without inhibiting the normal biology of tau and its role in microtubule stabilization. The number of compound classes being tested at this time are very limited and...
  
  

• Jan 20, 2010

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  Microwave Accelerated Synthesis of PET Image Contrast Agents for AD Research.

  Authors: Kallmerten AE, Jones GB Positron emission tomography (PET) imaging of Alzheimer's Disease (AD) offers the potential to provide early onset diagnosis and subsequent intervention, including guided treatment regimens. One of the restricting factors in clinical application of PET technology is the limited availability of radioligands with affinity to specific targets of...