Archive for January 19th, 2010
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Jan 19, 2010
No CommentsConsumers over age 50 should consider steps to cut copper and iron intake
(American Chemical Society) With scientific evidence linking high levels of copper and iron to Alzheimer's disease, heart disease, and other age-related disorders, a new report in ACS' Chemical Research in Toxicology suggests specific steps that older consumers can take to avoid build up of unhealthy amounts of these metals in their bodies. (Source: EurekAlert! -...
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Jan 19, 2010
No CommentsComment: Bapineuzumab for Alzheimer’s disease
Source: Lancet Neurology Area: News This commentary featured In Lancet Neurology describes the results of a randomised, double-blind, phase 2 study of bapineuzumab, an emerging immunotherapeutic strategy for the treatment of Alzheimer's Disease. The author highlights the importance of apolipoprotein E (APOE) ?4 allele carrier status which may affect the efficacy of this intervention. (Source: NeLM...
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Jan 19, 2010
No CommentsSigma-1 receptor agonist fluvoxamine for delirium in patients with Alzheimer’s disease
Conclusion: Doctors should consider that fluvoxamine could be an alternative approach in treating delirium in patients with Alzheimer's disease because of the risk of extrapyramidal side effects by antipsychotic drugs. (Source: Annals of General Psychiatry)MedWorm Message: Get the very latest Swine Flu news via the MedWorm Swine Flu RSS news feed - updated...
Jan 19, 2010
No CommentsCognitive Fluctuations May Predict Alzheimer’s Severity
In patients with Alzheimer's disease, the presence of cognitive fluctuations, spontaneous alterations in cognition, attention, and arousal, may be associated with greater disease severity and poorer neuropsychological performance, according to a study published in the Jan. 19 issue of Neurology. (Source: Modern...
Jan 19, 2010
No CommentsTranscriptional regulation of human FE65, a ligand of Alzheimer’s disease amyloid precursor protein, by Sp1
FE65 is a neuronal-enriched adaptor protein that binds to the Alzheimer's disease amyloid precursor protein (APP). FE65 forms a transcriptionally active complex with the APP intracellular domain (AICD). The precise gene targets for this complex are unclear but several Alzheimer's disease-linked genes have been proposed. Additionally, evidence suggests that FE65 influences APP metabolism. The mechanism...
Jan 19, 2010
No CommentsGenetic variations in tau-tubulin kinase-1 are linked to Alzheimer’s disease in a Spanish case-control cohort.
We examined genetic variations of TTBK1 by genotyping nine haplotype tagging SNPs (htSNPs) (rs2104142, rs2651206, rs10807287, rs7764257, rs3800294, rs1995300, rs2756173, rs6936397, and rs6458330) in a group of 645 Spanish late-onset AD patients and 738 healthy controls. Using a recessive genetic model, minor allele homozygotes for rs2651206 in intron 1 (OR=0.50, p=0.0003), rs10807287 in intron 5...
Jan 19, 2010
No CommentsGenome-wide association studies identify new interesting loci for late-onset Alzheimer’s disease.
Authors: Skotte N PMID: 20095981 [PubMed - as supplied by publisher] (Source: Clinical...
Jan 19, 2010
No CommentsCognitive Fluctuations Signal Onset of Alzheimer’s
Testing cognitive fluctuations should be considered when assessing Alzheimer's disease, say researchers. Medscape Medical News (Source: Medscape Today...
Jan 19, 2010
No CommentsDon’t Underestimate the Health Benefits of Singing: Experts
Studies suggest that singing is beneficial for physical health, including for people with Alzheimer's, asthma, and COPD, as well as for mental health, such as depression and...
Jan 19, 2010
No CommentsDrowsiness, staring and other mental lapses may signal Alzheimer’s disease
Cognitive fluctuations, or episodes when train of thought temporarily is lost, are more likely to occur in older persons who are developing Alzheimer's disease than in their healthy peers, according to scientists at Washington University School of Medicine in St. Louis. Cognitive fluctuations include excessive daytime sleepiness, staring into space and disorganized or illogical thinking....


