Alzheimer’s Group Resources

Tests can tell Alzheimer’s from dementia

ADELAIDE, Australia, July 9 (UPI) -- Alzheimer's disease and dementia affect memory and behavior but have different causes and require different treatment, Australian researchers say. (Source: Health News - UPI.com)

Fresh theory on Alzheimer’s

CHEMICALS found in many fruits and vegetables, as well as tea, cocoa and red wine, could protect the brain from Alzheimer's disease, a conference in Edinburgh heard today. (Source: Scotsman.com News - Health)

Fruit and veg could help to stem onset of Alzheimer’s

CHEMICALS in fruit and vegetables, as well as tea and red wine, could help to protect the brain against Alzheimer's disease, a conference will hear today. (Source: Scotsman.com News - Health)

Can Language Skills Ward Off Alzheimer’s Disease?

A small study of aging nuns illuminates the curious condition of "asymptomatic Alzheimer's disease" -- when brains show physical lesions, but patients display no signs of cognitive decline (Source: TIME.com: Top Science and Health Stories)

Costs are soaring in the age of Alzheimer’s

Age is the top risk factor for Alzheimer's disease (AD), so it's not surprising that the number of people with AD is expected to almost triple to 14 million by 2050, up from today's 5 million. Also not surprisingly, patients with AD and Alzheimer's disease-related dementias (ADRD) are heavy users of hospital and long-term care services, especially nursing home care, with estimated annual costs reaching tens of millions of dollars. (Source: Geriatrics Magazine)

[Mechanisms Of Signal Transduction] GRK5 Deficiency Leads to Reduced Hippocampal Acetylcholine Level via Impaired Presynaptic M2/M4 Autoreceptor Desensitization

G protein-coupled receptor kinase 5 (GRK5) deficiency has been linked recently to early Alzheimer disease (AD), but the mechanism by which GRK5 deficiency may contribute to AD pathogenesis remains elusive. Here we report that overexpression of dominant negative mutant of GRK5 (dnGRK5) in a cholinergic neuronal cell line led to decreased acetylcholine (ACh) release. This reduction was fully corrected by pertussis toxin, atropine (a nonselective muscarinic antagonist), or methoctramine (a selective M2/M4 muscarinic receptor antagonist). Consistent with results in cultured cells, high potassium-evoked ACh release in hippocampal slices from young GRK5 knock-out mice was significantly reduced compared with wild type littermates, and this reduced ACh release was also fully corrected by methoctra...

A surrogate marker for A[beta]42 production in the CNS

Alzheimer's disease (AD) is the most common cause of dementia. There are currently no effective treatments that may delay the onset, slow the progression or prevent the disease. Unless such treatments are developed, the number of AD cases is expected to double in the next 30 years. There is overwhelming genetic and biochemical evidence that the aggregation and buildup of the amyloid-[beta] (A[beta]) peptide plays a critical role in AD pathogenesis. (Source: EMBO Molecular Medicine)

Can Language Skills Ward Off Alzheimer’s? A Nuns’ Study

A small new study of aging nuns illuminates the curious condition of "asymptomatic Alzheimer's disease" -- brains show physical lesions but patients display no signs of cognitive decline (Source: TIME.com: Top Science and Health Stories)

Language skills may help predict Alzheimer’s risk

People with stronger language skills early in adulthood may be at a lower risk of experiencing symptoms of Alzheimer's disease decades later, a new study suggests. (Source: CBC | Health)

J&J Bets With Elan

Alzheimer's investment helps small firm survive. (Source: Chemical and Engineering News)