Archive for July 8th, 2009
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Jul 08, 2009
No CommentsHappy Days: Living in the Moment
A daughter turns to her study of yoga to help her understand her mother's Alzheimer's disease. (Source: NYT >...
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Jul 08, 2009
No CommentsMMP-2 downregulation mediates differential regulation of cell death via ErbB-2 in glioma xenografts.
Authors: Gondi CS, Dinh DH, Klopfenstein JD, Gujrati M, Rao JS The epidermal growth factor receptor (EGFR) family (also known as the ErbB protein family) is comprised of four structurally-related receptor tyrosine kinases. Insufficient ErbB signaling in humans is associated with the development of neurodegenerative diseases, such as multiple sclerosis and Alzheimer's...
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Jul 08, 2009
No CommentsLanguage ‘predicts dementia risk’
People with superior language skills early in life may be less likely to get Alzheimer's later, research suggests. (Source: BBC News | Health | UK...
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Jul 08, 2009
No CommentsSominone enhances neurite outgrowth and spatial memory mediated by the neurotrophic factor receptor, RET
Conclusions and implications: Sominone could reinforce the morphological plasticity of neurons by activation of the RET pathway and thus enhance memory. Sominone, a compound with low molecular weight, may be a GDNF-independent stimulator of the RET pathway and/or a novel modulator of RET signalling. (Source: British Journal of...
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Jul 08, 2009
No CommentsInhibition of tau fibrillization by oleocanthal via reaction with the amino groups of tau
Tau is a microtubule-associated protein that promotes microtubule assembly and stability. In Alzheimer's disease and related tauopathies, tau fibrillizes and aggregates into neurofibrillary tangles. Recently, oleocanthal isolated from extra virgin olive oil was found to display non-steroidal anti-inflammatory activity similar to ibuprofen. As our unpublished data indicates an inhibitory effect of oleocanthal on amyloid [beta]...
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Jul 08, 2009
No CommentsHypertrophy May Be the Key to Silent Alzheimer’s Disease
The brain cells of people with asymptomatic Alzheimer's disease undergo significant hypertrophy, which may be a compensatory mechanism to prevent cognitive impairment, according to a study published online July 8 in Neurology. (Source: Modern...
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Jul 08, 2009
No CommentsAstraZeneca to Advance AZD3480 in ADHD
AstraZeneca plans to conduct further development of AZD3480 by initiating Phase IIb studies in attention deficit/hyperactivity disorder (ADHD) and has agreed to make a $10 million milestone payment to Targacept. AstraZeneca also plans to continue development of AZD1446 (TC-6683) for Alzheimer's disease. AZD1446 is currently in Phase 1 and was discovered in the ongoing AstraZeneca-Targacept...
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Jul 08, 2009
No CommentsD10S1423 identifies a susceptibility locus for Alzheimer’s disease (AD7) in a prospective, longitudinal, double-blind study of asymptomatic individuals: Results at 14 years
This report describes the prospective, longitudinal, double-blind assessment of the age-specific risk of AD encountered by 325 asymptomatic first-degree relatives of AD probands who carried the D10S1423 (AD7) 234 bp allele, the APOE E4 allele, or both, after 14 years of systematic follow-up. A total of 30 incident cases of AD were detected during the...
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Jul 08, 2009
No CommentsEarly Language Abilities May Protect Memory Decades Later (CME/CE, with audio)
SAN FRANCISCO (MedPage Today) -- Sophisticated language skills in early adulthood may protect against the symptoms of Alzheimer's disease even when its characteristic brain lesions are present later in life, researchers found. (Source: MedPage Today...
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Jul 08, 2009
No CommentsBetter language skills may keep Alzheimer’s at bay
NEW YORK (Reuters Health) - People with more developed language skills as young adults may be better able to stay sharp well into old age, even if they develop Alzheimer's-like abnormalities in their brains, new research in the journal Neurology shows. (Source: Reuters:...
