Archive for July 2nd, 2009

• Jul 02, 2009

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  Losing a loved one in middle age can treble risk of developing dementia

  MIDDLE-AGED people who live alone may have double the risk of developing dementia and Alzheimer's disease in later life compared with those who are married or living with (Source: Scotsman.com News -...
  
  

• Jul 02, 2009

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  J&J Pays $1.5 Billion for Elan Stake

  J&J will buy an 18.4% stake in Irish biotech company Elan, in a bid to crack the potentially lucrative Alzheimer's market. (Source: WSJ.com:...
  
  

• Jul 02, 2009

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  Living Alone Increases Odds of Developing Dementia

  Losing a partner through divorce or death in middle age may triple the risk, study shows Source: HealthDay Related MedlinePlus Topics: Alzheimer's Disease, Dementia, Seniors' Health (Source: MedlinePlus Health News)

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• Jul 02, 2009

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  Alzheimer’s disease summit: Translating research advances into clinical practice

  The Alzheimer's Disease Summit, held on May 3, 2008, translated cutting-edge research into day-to-day practice. This supplement, based on information presented at the summit, presents valuable clinical content to a broad audience of primary care physicians, psychiatrists, geriatricians, and neurologists. (Source: Geriatrics...
  
  

• Jul 02, 2009

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  Single Status at Middle-Age May Affect Alzheimer’s Risk

  Middle-aged people who are widowed or divorced are more likely than their cohabiting counterparts to have cognitive impairment and Alzheimer's disease in later life, according to a study published online on July 2 in BMJ. (Source: Modern...
  
  

• Jul 02, 2009

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  [Protein Structure and Folding] Insulin Receptor Dysfunction Impairs Cellular Clearance of Neurotoxic Oligomeric A{beta}

  In this study we investigate whether impairments of insulin and insulin-like growth factor-1 (IGF-1) receptors play a role in aggregation of Aβ. Using primary neuronal culture and immortal cell line models, we show that expression of normal insulin or IGF-1 receptors confers cells with abilities to reduce exogenously applied Aβ oligomers (also known as ADDLs)...
  
  

• Jul 02, 2009

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  [Metabolism and Bioenergetics] Caspase-cleaved Tau Expression Induces Mitochondrial Dysfunction in Immortalized Cortical Neurons: IMPLICATIONS FOR THE PATHOGENESIS OF ALZHEIMER DISEASE

  In this study we investigated the effects of T4C3 on mitochondrial function. Expression of T4C3 induced mitochondrial fragmentation and elevated oxidative stress levels in comparison with T4-expressing cells. Thapsigargin treatment of T4 or T4C3 cells, which causes an increase in intracellular calcium levels, resulted in a significant decrease in mitochondrial potential and loss of mitochondrial...
  
  

• Jul 02, 2009

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  J&J to Buy Elan Stake

  J&J will buy an 18.4% stake in Irish biotech company Elan, in a $1.5 billion bid to crack the potentially lucrative Alzheimer's market. (Source: WSJ.com: Health)

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• Jul 02, 2009

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  J&J takes on Alzheimer’s disease with $1B stake in Elan

  Johnson & Johnson, making a big jump into the risky but potentially lucrative field of Alzheimer's disease, is taking a major ... (Source: USATODAY.com...
  
  

• Jul 02, 2009

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  Noggin and BMP4 co-modulate adult hippocampal neurogenesis in the APP(swe)/PS1(DeltaE9) transgenic mouse model of Alzheimer’s disease.

  We report that decreased neurogenesis in the APP/PS1 transgenic mice was accompanied by increased expression of BMP4 and decreased expression of Noggin at both the mRNA and protein levels; statistical analysis showed that the number of proliferative cells at different ages correlated positively with Noggin expression and negatively with BMP4 expression. Intraventricular administration of a...