Alzheimer’s Group Resources

Charities warn dementia funding must triple

Dementia research funding needs to be tripled to prevent the burden of the disease causing a financial crisis, Alzheimer's disease charities have warned. (Source: HealthcareRepublic Pharmacist News)

Charities warn dementia funding must triple

Dementia research funding needs to be tripled to prevent the burden of the disease causing a financial crisis, Alzheimer's disease charities have warned. (Source: Healthcare Republic News)

Relationship between ALS and the degree of cognitive impairment, markers of neurodegeneration and predictors for poor outcome. A prospective study

Conclusion: In our prospective study, age, disease severity and CSF beta-amyloid levels taken together were a risk factor suggesting shorter survival times. Dementia is relatively frequent in ALS and may be a consequence of either FTLD or result from co-existing Alzheimer disease. (Source: European Journal of Neurology)

Distribution of neurofibrillary tangles in diffuse neurofibrillary tangles with calcification

Conclusions: The diffuse appearance of NFT in the cerebral cortex with the highest severity in the temporal pole was found to be a neuropathological characteristic of DNTC. (Source: Psychiatry and Clinical Neurosciences)

Ultimate Love Triangle: An Aging Mother-in-Law

Caring for mother-in-law with Alzheimer's nearly drives couple to divorce. (Source: ABC News: Health)

Apathy: A Common Psychiatric Syndrome in the Elderly

This article reviews the definition of apathy, prevalence and associated adverse outcomes, causation, the approach to patients with apathy, and available treatment options with particular attention to studies conducted in a nursing home setting. The purpose of this article is to increase the recognition of apathy by physicians working in the nursing home. (Source: Journal of the American Medical Directors Association)

Carotid Artery Ultrasound and Echocardiography Testing to Lower the Prevalence of Alzheimer’s Disease

The use of two clinic office techniques, carotid artery ultrasound and echocardiography (CAUSE), to detect deficient brain blood flow delivery in the healthy, cognitively normal, older individual is proposed. Evidence indicates that persistent heart-to-brain blood flow deficit involving low cardiac output or low ejection fraction and carotid artery narrowing can promote cognitive impairment and that such impairment may lead to Alzheimer's disease (AD) or vascular dementia (VaD). A number of independent epidemiologic studies reported cardiovascular and cerebrovascular disease to be risk factors to AD and VaD. The clinical rationale for CAUSE is to detect and prevent progression of cognitive dysfunction in elderly persons and is based on the general understanding that mild cognitive impairme...

Abstract #1: Cognitive Function Data in Newly Diagnosed AED-Naïve Epilepsy Patients Across a Broad Age Range

Conclusions: These data may be useful in the analysis and interpretation of cognitive assessment data from clinical trials of AEDs and/or studies in similar patient populations.Financial disclosure: This study was sponsored by AstraZeneca. None of the authors has a financial relationship with the sponsor. (Source: Neurotherapeutics)

Abstract #3: APP Secretases As Therapeutic Targets for Traumatic Brain Injury

Traumatic brain injury (TBI) is a significant risk factor for the development of Alzheimer's disease, and post mortem studies show that 30% of TBI fatalities have amyloid-2 (A2) deposits. Remarkably, these deposits occur less than one day after injury. Not only does A2 accumulate after TBI, but so do the necessary amyloid precursor protein (APP) enzymes responsible for A2 production: BACE1 protein (2-secretase) and the gamma-secretase complex protein presenilin-1 (PS-1). In order to understand the role of these secretases in brain trauma, we targeted 2- and gamma-secretases with genetic knockout (BACE1−/−) and pharmacological inhibition (DAPT treatment) in an experimental model of TBI.We exposed WT and BACE1−/− mice and vehicle- and DAPT-treated C57/Bl6 mice to the controlled corti...

How to get quick help in the ER

The average total wait time in an emergency room in the United States is four hours and three minutes, but experts say there are ways you can cut down your wait.