Archive for April 26th, 2009
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Apr 26, 2009
No CommentsObama Administration Looking To Increase Physician Supply Without Increasing Costs
The Obama administration is taking steps to address a nationwide shortage of physicians in order to meet the needs of an aging population and millions of uninsured people who would receive health insurance under legislation supported by the president, the New York Times reports. According to the Times, administration officials are especially concerned about a...
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Apr 26, 2009
No CommentsSUMO protein guides chromatin remodeler to suppress genes
(Tufts University, Health Sciences) Researchers have uncovered a mechanism involved in ensuring that only certain genes are expressed in a specific cell type. This discovery advances the understanding of cancer and neurodegenerative diseases such as Alzheimer's. (Source: EurekAlert! -...
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Apr 26, 2009
No CommentsNovel role of protein in generating amyloid-beta peptide
(University of California - San Diego) A defining hallmark of Alzheimer's disease is the accumulation of the amyloid-beta protein, otherwise known as "senile plaques," in the brain's cortex and hippocampus, where memory consolidation occurs. Researchers at the University of California, San Diego School of Medicine have identified a novel protein which, when over-expressed, leads to...
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Apr 26, 2009
No CommentsDrug-Like Compounds Break Down Alzheimer’s Protein
Two small molecules can promote the breakdown of amyloid β-protein, which accumulates in the brain in patients with Alzheimer's disease and is implicated in disease pathogenesis, according to a report published online April 22 in PLoS ONE. (Source: Modern...
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Apr 26, 2009
No CommentsEffect of APOE genotype on amyloid plaque load and gray matter volume in Alzheimer disease
Conclusion: These results indicate that the 4-positive APOE genotype not only represents a risk factor for Alzheimer disease (AD), but also results in higher levels of Aβ plaque deposition in 4-positive patients with AD compared to age-matched 4-negative patients with similar levels of cognitive impairment and brain atrophy. The potential role of Aβ plaque imaging...
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Apr 26, 2009
No CommentsNeuropathologic intermediate phenotypes enhance association to Alzheimer susceptibility alleles
Conclusion: Discovery efforts for susceptibility loci for Alzheimer disease could benefit from the use of neuropathologic intermediate phenotypes as a complement to other approaches. (Source:...
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Apr 26, 2009
No CommentsIn vivo mapping of amyloid toxicity in Alzheimer disease
Conclusion: The medial temporal lobe might be highly susceptible to amyloid toxicity, whereas neocortical areas might be more resilient. (Source:...
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Apr 26, 2009
No CommentsRisk of dementia in MCI: Combined effect of cerebrovascular disease, volumetric MRI, and 1H MRS
Conclusions: Multiple magnetic resonance (MR) markers of underlying dementia pathologies improve the ability to identify patients with prodromal dementia over a single MR marker, supporting the concept that individuals with multiple brain pathologies have increased odds of dementia compared with individuals with a single pathology. (Source: Neurology)MedWorm Message: Get the very latest Swine Flu news...
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Apr 26, 2009
No CommentsSoluble aggregates of the amyloid-beta peptide are trapped by serum albumin to enhance amyloid-beta activation of endothelial cells
Conclusions: These results demonstrate that inhibitors of Abeta self-assembly have the potential to trap small soluble aggregates resulting in an elevation rather than a reduction of cellular responses. These findings provide further support that small soluble aggregates possess high levels physiological activity and underscore the importance of resolving the effect of Abeta aggregation inhibitors on aggregate...
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Apr 26, 2009
No CommentsCanada becomes third nation to confirm swine flu cases
Canada became the third country to confirm human cases of swine flu Sunday as other nations considered wider measures to curb the spread of the...
