Archive for July 9th, 2008
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Jul 09, 2008
Comments OffNovel drug ionophore shows potential for alzheimer’s
Scientists report a remarkable improvement in Alzheimer's transgenic mice following treatment with a new drug. The study, published by Cell Press in the July 10th issue of the journal Neuron, provides the first demonstration that an ionophore, a compound that transports metal ions across cell membranes, can elicit rapid and pronounced improvement in neuropathology and...
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Jul 09, 2008
Comments OffNeuron to publish prana’s pbt2 preclinical research on alzheimer’s disease
Prana Biotechnology Ltd. has announced the publication of key research findings with its lead Alzheimer's Disease drug, PBT2. (Source: News-Medical News Feed)...
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Jul 09, 2008
Comments OffThe neuropsychological profile in dementia with lewy bodies and alzheimer’s disease
To demonstrate the exact nature of the cognitive profile of dementia with Lewy bodies (DLB) on standardized neuropsychological tests including the Wechsler Adult Intelligence Scale--Revised (WAIS-R) and the Wechsler Memory Scale--Revised (WMS-R).We examined the WAIS-R and the WMS-R of 26 patients with probable DLB (based on the Consensus Criteria for the clinical diagnosis of DLB)...
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Jul 09, 2008
Comments OffEffects of alzheimer’s disease and mild cognitive impairment on driving ability: a controlled clinical study by simulated driving test
To assess the effects of Alzheimer's disease (AD) and Mild Cognitive Impairment (MCI) on simulated car driving ability.Twenty patients with a probable AD of mild severity (Clinical Dementia Rating, CDR = 1) were compared with 20 subjects with MCI (CD = 0.5), and a group of age-matched neurologically normal controls on a driving simulation task....
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Jul 09, 2008
Comments OffImpact of apoe status on cognitive maintenance in healthy elderly persons
The [epsiv]4 allele, a variant of the apolipoprotein E (ApoE) gene, is the most prominent genetic risk factor for sporadic, non-familial Alzheimer's disease (AD) currently known. We investigated the impact of the ApoE-[epsiv]4 status on cognitive performance at repeated test administration in elderly non-symptomatic persons, with a specific focus on practice effects.Three hundred and fifty-five...
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Jul 09, 2008
No CommentsResearchers find second genetic risk factor for alzheimer’s
Researchers led by Philippe Marambaud of the Feinstein Institute for Medical Research and Albert Einstein College of Medicine have identified a second gene that increases the risk for late-onset Alzheimer's... (Source: About Alzheimers Disease)MedWorm Sponsored Message: Find out how you can get your message across here by sponsoring this MedWorm news...
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Jul 09, 2008
No CommentsMolecular mechanisms of the conjugated {alpha},{beta}-unsaturated carbonyl derivatives: relevance to neurotoxicity and neurodegenerative diseases
Conjugated ,β-unsaturated carbonyl derivatives such acrylamide, acrolein, and 4-hydroxy-2-nonenal (HNE) are members of a large class of chemicals known as the type-2 alkenes. Human exposure through diet, occupation, and pollution is pervasive and has been linked to toxicity in most major organs. Evidence suggests that these soft electrophiles produce toxicity by a common mechanism involving...
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Jul 09, 2008
No CommentsMonocyte chemoattractant protein-1 plays a dominant role in the chronic inflammation observed in alzheimer’s disease
Chronic neuroinflammation correlates with cognitive decline and brain atrophy in Alzheimer's disease (AD), and cytokines and chemokines mediate the inflammatory response. However, quantitation of cytokines and chemokines in AD brain tissue has only been carried out for a small number of mediators with variable results. We simultaneously quantified 17 cytokines and chemokines in brain tissue...
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Jul 09, 2008
No CommentsBehavior of hippocampal stem/progenitor cells following grafting into the injured aged hippocampus
Multipotent neural stem/progenitor cells (NSCs) from the embryonic hippocampus are potentially useful as donor cells to repopulate the degenerated regions of the aged hippocampus after stroke, epilepsy, or Alzheimer's disease. However, the efficacy of the NSC grafting strategy for repairing the injured aged hippocampus is unknown. To address this issue, we expanded FGF-2-responsive NSCs from...
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Jul 09, 2008
Comments OffIonophore reverses alzheimer’s within days
Researchers report a remarkable improvement in Alzheimer's transgenic mice following therapy with a new drug. The study, published by Cell Press in the July 10th issue of the journal Neuron, provides the first demonstration that an ionophore, a compound that transports metal ions across cell membranes, can elicit rapid and pronounced improvement in neuropathology and...
